The Parker Lab at the University of Michigan is part of the Departments of Computational Medicine & Bioinformatics, Human Genetics, and Biostatistics, and is affiliated with the Genome Science Training Program at the Center for Statistical Genetics, the Genetics Training Program, and the Center for RNA Biomedicine.

We study the effects of genetic variation on chromatin architecture and transcriptional regulation at single-cell resolution. Our research group uses an integrative approach in the general fields of computational biology and functional genomics. The major goal of the lab is to generate mechanistic knowledge about how personalized disease predisposition is encoded in cell and state-specific transcriptional regulatory circuits, with a focus on complex metabolic diseases including diabetes and related traits.